5/25/2025
Last update
5/25/2025
Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Questionable
Based on 5 Researches
5.8
USERS' SCORE
Good
Based on 24 Reviews
8.9
Supplement Facts
Serving Size: 3 Capsules
Serving Per Container: 120
Amount Per Serving
%DV
MSM (Methylsulfonylmethane) (OptiMSM®)
3,000 mg
†
Top Medical Research Studies
8
We explored the effects of methylsulfonylmethane (MSM) on knee pain through a well-structured randomized, double-blind, placebo-controlled trial.
Involving 88 healthy participants, the study compared the outcomes of those taking MSM against a placebo over a 12-week period.
Results showed that MSM significantly improved knee health and overall well-being according to the Japanese Knee Osteoarthritis Measure, with a notable difference in scores between the two groups.
This suggests that MSM could be a helpful option for those dealing with mild knee pain.
Involving 88 healthy participants, the study compared the outcomes of those taking MSM against a placebo over a 12-week period.
Results showed that MSM significantly improved knee health and overall well-being according to the Japanese Knee Osteoarthritis Measure, with a notable difference in scores between the two groups.
This suggests that MSM could be a helpful option for those dealing with mild knee pain.
Read More
4
We conducted a double-blind, randomized controlled trial to assess the effectiveness of methylsulfonylmethane (MSM) for knee osteoarthritis (OA). Fifty participants aged 45 to 90 received either MSM or a placebo over 12 weeks.
Although we observed some improvement in pain and physical function for those taking MSM, these changes were minimal and may not hold clinical significance. Hence, while there are some positive effects, the overall benefits of MSM for treating knee OA remain uncertain.
Although we observed some improvement in pain and physical function for those taking MSM, these changes were minimal and may not hold clinical significance. Hence, while there are some positive effects, the overall benefits of MSM for treating knee OA remain uncertain.
Read More
2
We examined the impact of methylsulfonylmethane (MSM) on knee pain in military trainees. In a randomized controlled trial, 180 participants, aged 18 to 40, either received 3 grams of MSM or a placebo for 8 weeks.
Unfortunately, our findings showed no significant improvements in knee pain levels or mood scores among those taking MSM compared to the placebo group. Although MSM can be safely consumed, it seems it may not effectively prevent knee pain in active individuals.
Unfortunately, our findings showed no significant improvements in knee pain levels or mood scores among those taking MSM compared to the placebo group. Although MSM can be safely consumed, it seems it may not effectively prevent knee pain in active individuals.
Read More
Most Useful Reviews
10
No knee discomfort
102 people found this helpful
I purchased this item for my mother after she was diagnosed with minor osteoarthritis. She has been taking it for a couple of months and has stopped experiencing discomfort in her knees.
Read More
10
Exciting results
4 people found this helpful
The most effective ligament and joint supplement I have ever used! I saw results within two weeks of using MSM with marine collagen. However, I believe collagen might not be necessary for reaching my desired outcome. I highly recommend this to anyone experiencing joint and ligament issues, especially in the knees and elbows.
Read More
10
Superb joint results
2 people found this helpful
Tested product delivers excellent results for joints, especially the knee, and is suitable for both the elderly and younger people, including bodybuilders.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 5 Researches
5.8
- All Researches
8
We explored the effects of methylsulfonylmethane (MSM) on knee pain through a well-structured randomized, double-blind, placebo-controlled trial.
Involving 88 healthy participants, the study compared the outcomes of those taking MSM against a placebo over a 12-week period.
Results showed that MSM significantly improved knee health and overall well-being according to the Japanese Knee Osteoarthritis Measure, with a notable difference in scores between the two groups.
This suggests that MSM could be a helpful option for those dealing with mild knee pain.
Involving 88 healthy participants, the study compared the outcomes of those taking MSM against a placebo over a 12-week period.
Results showed that MSM significantly improved knee health and overall well-being according to the Japanese Knee Osteoarthritis Measure, with a notable difference in scores between the two groups.
This suggests that MSM could be a helpful option for those dealing with mild knee pain.
Read More
8
We assessed the impact of an 8-week joint pain supplement, Instaflex™, on adults aged 50-75 experiencing knee pain. In a randomized, double-blind, placebo-controlled trial with 100 participants, we measured changes in pain, stiffness, and daily function.
Our findings revealed that Instaflex™ significantly reduced knee pain severity and improved the ability to perform daily activities, particularly beneficial for those suffering from chronic knee discomfort. This suggests that the supplement could be a helpful option for managing knee pain in older adults.
Our findings revealed that Instaflex™ significantly reduced knee pain severity and improved the ability to perform daily activities, particularly beneficial for those suffering from chronic knee discomfort. This suggests that the supplement could be a helpful option for managing knee pain in older adults.
Read More
7
We conducted a randomized, double-blind, placebo-controlled trial to see if methylsulfonylmethane (MSM) helps alleviate knee pain in people with osteoarthritis. Over 12 weeks, participants took either 3g of MSM or a placebo, twice daily.
We observed significant improvements in pain and physical function for those taking MSM compared to the placebo group. However, no major side effects were reported, and some assessments did not show clear benefits. While MSM showed promise, more research is needed to confirm its long-term effectiveness and safety.
We observed significant improvements in pain and physical function for those taking MSM compared to the placebo group. However, no major side effects were reported, and some assessments did not show clear benefits. While MSM showed promise, more research is needed to confirm its long-term effectiveness and safety.
Read More
4
We conducted a double-blind, randomized controlled trial to assess the effectiveness of methylsulfonylmethane (MSM) for knee osteoarthritis (OA). Fifty participants aged 45 to 90 received either MSM or a placebo over 12 weeks.
Although we observed some improvement in pain and physical function for those taking MSM, these changes were minimal and may not hold clinical significance. Hence, while there are some positive effects, the overall benefits of MSM for treating knee OA remain uncertain.
Although we observed some improvement in pain and physical function for those taking MSM, these changes were minimal and may not hold clinical significance. Hence, while there are some positive effects, the overall benefits of MSM for treating knee OA remain uncertain.
Read More
2
We examined the impact of methylsulfonylmethane (MSM) on knee pain in military trainees. In a randomized controlled trial, 180 participants, aged 18 to 40, either received 3 grams of MSM or a placebo for 8 weeks.
Unfortunately, our findings showed no significant improvements in knee pain levels or mood scores among those taking MSM compared to the placebo group. Although MSM can be safely consumed, it seems it may not effectively prevent knee pain in active individuals.
Unfortunately, our findings showed no significant improvements in knee pain levels or mood scores among those taking MSM compared to the placebo group. Although MSM can be safely consumed, it seems it may not effectively prevent knee pain in active individuals.
Read More
User Reviews
USERS' SCORE
Good
Based on 24 Reviews
8.9
- All Reviews
- Positive Reviews
- Negative Reviews
10
No knee discomfort
102 people found this helpful
I purchased this item for my mother after she was diagnosed with minor osteoarthritis. She has been taking it for a couple of months and has stopped experiencing discomfort in her knees.
Read More
10
Exciting results
4 people found this helpful
The most effective ligament and joint supplement I have ever used! I saw results within two weeks of using MSM with marine collagen. However, I believe collagen might not be necessary for reaching my desired outcome. I highly recommend this to anyone experiencing joint and ligament issues, especially in the knees and elbows.
Read More
10
Superb joint results
2 people found this helpful
Tested product delivers excellent results for joints, especially the knee, and is suitable for both the elderly and younger people, including bodybuilders.
Read More
10
No more knee pain
1 people found this helpful
Initially, I purchased it for myself after reading positive reviews, but I later bought it for the whole family as I experienced genuine results. My knee used to hurt often, making it challenging to descend stairs. Now, I’ve completely forgotten about this issue. I hope my review helps someone.
Read More
9
Surprising results
1 people found this helpful
I had back and knee pain, and after starting this treatment, I was amazed that those pains vanished. My husband was surprised too; his skin improved dramatically! MSM is incredible.
Read More
Frequently Asked Questions
9
Crunching resolved
1 people found this helpful
After my knee cracked during training, it crunched for about a month. I started taking one capsule daily, and within a week, the crunching stopped! I’m thrilled with the results and continue for prevention. I also recommend it to my husband post-knee surgery.
10
Exciting results
4 people found this helpful
The most effective ligament and joint supplement I have ever used! I saw results within two weeks of using MSM with marine collagen. However, I believe collagen might not be necessary for reaching my desired outcome. I highly recommend this to anyone experiencing joint and ligament issues, especially in the knees and elbows.
10
No knee discomfort
102 people found this helpful
I purchased this item for my mother after she was diagnosed with minor osteoarthritis. She has been taking it for a couple of months and has stopped experiencing discomfort in her knees.
7.5
Stopped knee pain
1 people found this helpful
After experiencing knee pain, I researched and created a treatment plan that included glucosamine and chondroitin, hyaluronic acid, and MSM. After six months of this regimen, my knee pain ceased. To maintain progress, I plan to repeat the course in six months.
10
No more knee pain
1 people found this helpful
Initially, I purchased it for myself after reading positive reviews, but I later bought it for the whole family as I experienced genuine results. My knee used to hurt often, making it challenging to descend stairs. Now, I’ve completely forgotten about this issue. I hope my review helps someone.
7.5
Mobility improved
3 people found this helpful
I take MSM on the recommendation of a surgeon due to osteoarthritis of the knee and ankle joints. I use it not for treatment but as supportive therapy. Alongside my main treatment, I’ve noticed a significant improvement in joint mobility. My hair has grown thicker. I take two capsules daily and will certainly continue since it has produced results!
7.5
Knee joint improvement
1 people found this helpful
Taking 2 MSM and 2 vitamin C three times a day has greatly improved my knee joint.
9
Improved knee function
1 people found this helpful
I took Doctor's Best glucosamine, chondroitin, and MSM for three months, and my knee improved significantly. My relatives followed my advice and experienced similar relief. We are now on our second course.
8
We explored the effects of methylsulfonylmethane (MSM) on knee pain through a well-structured randomized, double-blind, placebo-controlled trial.
Involving 88 healthy participants, the study compared the outcomes of those taking MSM against a placebo over a 12-week period.
Results showed that MSM significantly improved knee health and overall well-being according to the Japanese Knee Osteoarthritis Measure, with a notable difference in scores between the two groups.
This suggests that MSM could be a helpful option for those dealing with mild knee pain.
Involving 88 healthy participants, the study compared the outcomes of those taking MSM against a placebo over a 12-week period.
Results showed that MSM significantly improved knee health and overall well-being according to the Japanese Knee Osteoarthritis Measure, with a notable difference in scores between the two groups.
This suggests that MSM could be a helpful option for those dealing with mild knee pain.
2
We examined the impact of methylsulfonylmethane (MSM) on knee pain in military trainees. In a randomized controlled trial, 180 participants, aged 18 to 40, either received 3 grams of MSM or a placebo for 8 weeks.
Unfortunately, our findings showed no significant improvements in knee pain levels or mood scores among those taking MSM compared to the placebo group. Although MSM can be safely consumed, it seems it may not effectively prevent knee pain in active individuals.
Unfortunately, our findings showed no significant improvements in knee pain levels or mood scores among those taking MSM compared to the placebo group. Although MSM can be safely consumed, it seems it may not effectively prevent knee pain in active individuals.
8
We assessed the impact of an 8-week joint pain supplement, Instaflex™, on adults aged 50-75 experiencing knee pain. In a randomized, double-blind, placebo-controlled trial with 100 participants, we measured changes in pain, stiffness, and daily function.
Our findings revealed that Instaflex™ significantly reduced knee pain severity and improved the ability to perform daily activities, particularly beneficial for those suffering from chronic knee discomfort. This suggests that the supplement could be a helpful option for managing knee pain in older adults.
Our findings revealed that Instaflex™ significantly reduced knee pain severity and improved the ability to perform daily activities, particularly beneficial for those suffering from chronic knee discomfort. This suggests that the supplement could be a helpful option for managing knee pain in older adults.
7
We conducted a randomized, double-blind, placebo-controlled trial to see if methylsulfonylmethane (MSM) helps alleviate knee pain in people with osteoarthritis. Over 12 weeks, participants took either 3g of MSM or a placebo, twice daily.
We observed significant improvements in pain and physical function for those taking MSM compared to the placebo group. However, no major side effects were reported, and some assessments did not show clear benefits. While MSM showed promise, more research is needed to confirm its long-term effectiveness and safety.
We observed significant improvements in pain and physical function for those taking MSM compared to the placebo group. However, no major side effects were reported, and some assessments did not show clear benefits. While MSM showed promise, more research is needed to confirm its long-term effectiveness and safety.
References
- Toguchi A, Noguchi N, Kanno T, Yamada A. Methylsulfonylmethane Improves Knee Quality of Life in Participants with Mild Knee Pain: A Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients. 2023;15. 10.3390/nu15132995
- Tennent DJ, Hylden CM, Kocher BK, Aden JK, Johnson AE. A randomized controlled trial evaluating methylsulfonylmethane versus placebo to prevent knee pain in military initial entry trainees. US Army Med Dep J. 2017.
- Nieman DC, Shanely RA, Luo B, Dew D, Meaney MP, et al. A commercialized dietary supplement alleviates joint pain in community adults: a double-blind, placebo-controlled community trial. Nutr J. 2013;12:154. 10.1186/1475-2891-12-154
- Debbi EM, Agar G, Fichman G, Ziv YB, Kardosh R, et al. Efficacy of methylsulfonylmethane supplementation on osteoarthritis of the knee: a randomized controlled study. BMC Complement Altern Med. 2011;11:50. 10.1186/1472-6882-11-50
- Kim LS, Axelrod LJ, Howard P, Buratovich N, Waters RF. Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial. Osteoarthritis Cartilage. 2006;14:286.
